Background: Pregnancy and the puerperium are well-established risk factors for VTE. It is estimated that the incidence of VTE during pregnancy is between 10 to 20 events per 10,000. Recently, we reported that the incidence of VTE in the Korean population is approximately one-tenth to one-fifth of the incidence reported in the Caucasian population. As an extension of the epidemiologic study that investigated the difference between ethnicities, we carried out the pregnancy-associated VTE study in the Korean population to provide basic information regarding the incidence of pregnancy-associated VTE.. Methods: The Korean Health Insurance Review and Assessment Service database was used to retrospectively identify cases of pregnancy-associated VTE from 2006 to 2010. Cases were indentified based upon diagnostic and treatment evidence of VTE among the all delivered women. Results: A total of 147 cases of pregnancy-associated VTE were identified during the study period. The total incidence of pregnancy-associated VTE was 0.82 (per 10,000 deliveries) (95% CI, 0.69-0.96). The annual incidence of pregnancy-associated VTE was 0.70 in 2006, 0.58 in 2007, 0.72 in 2008, 1.04 in 2009, and 1.06 in 2010, which suggest that the incidence of pregnancy-associated VTE increased steadily from 2007 to 2010. The incidence of pregnancy-associated VTE (per 10,000 deliveries) was 0.47 (95% CI, 0.17-1.03) at 15-24 years of age, 0.71 (95% CI, 0.52-0.94) at 25-29 years of age, 0.76 (95% CI, 0.57-0.98) at 30-34 years of age, 1.47 (95% CI, 0.99-2.10) at 35-40 years of age, and 2.33 (95% CI, 0.76-5.43) at over 40 years of age which suggest that the incidence of pregnancy-associated VTE increased steadily with age. The OR for VTE were 1.07 (95% CI, 0.73-1.57; P = 0.73) at 30-34 years of age, 2.08 (95% CI, 1.32-3.28; P = 0.002) at 35-40 years of age, and 3.29 (95% CI, 1.31-8.26; P = 0.01) at over 40 years of age. Conclusions: This study demonstrates a lower incidence of pregnancy-associated VTE in Asian compared with Caucasian populations; however, it also demonstrates a yearly increasing incidence of pregnancy-associated VTE and maternal age in pregnancy is the risk of pregnancy-associated VTE in the Korean population. (2011년 9월 J Thromb Haemost에 accept 됨)
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